A worldwide yearly survey of new data and trends in adverse by J.K. Aronson (Eds.)

By J.K. Aronson (Eds.)

Quantity 28 within the sequence of unintended effects of substances Annuals (http://www.elsevier.com/locate/series/seda) keeps to serve its basic aim: to supply clinicians and scientific investigators with a competent and significant every year survey of latest info and developments within the region of inauspicious Drug Reactions and Interactions. a world workforce of experts has reviewed new facts and tendencies by means of identifying from the year's writing all that's actually new and informative, through significantly reading it, and by way of pointing to no matter what is unproven or deceptive. using the booklet is superior through separate indexes, permitting the reader to entry the textual content through drug identify, hostile influence, or drug interplay. the present annual contains an essay through the editor, Dr Jeffrey Aronson, entitled 'Classifying Drug adversarial Reactions within the twenty first Century.' In it he describes how the fashionable method of classifying antagonistic drug reactions takes under consideration the dose that reasons the response, the time-course of the response, and the susceptibility elements that elevate the person patient's probability, and indicates how this research can facilitate regulatory choice making. *Provides a serious each year survey of latest facts and trends*Includes an essay that describes the fashionable method of classifying adversarial drug reactions*Special reports during this Annual contain, between different themes: Antipsychotic medicinal drugs and now-onset diabetes mellitus, Treating bronchial asthma while pregnant, and MMR vaccine and autism

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Validation of brief observation period for patients with cocaine-associated chest pain. New Engl J Med 2003; 348: 510–17. 28. Honderick T, Williams D, Seaberg D, Wears R. A prospective, randomized, controlled trial of benzodiazepines and nitroglycerine or nitroglycerine alone in the treatment of cocaine-associated acute coronary syndromes. Am J Emerg Med 2003; 21: 39–42. 29. Baumann BM, Perrone J, Hornig SE, Shofer FS, Hollander JE. Randomized, double-blind, placebo-controlled trial of diazepam, nitroglycerine, or both for treatment of patients with potential cocaine-associated acute coronary syndromes.

A protocol of this sort should incorporate strategies for treating substance abuse, since there is an increased likelihood of non-fatal myocardial infarction in patients who continue to use cocaine. In a randomized, controlled trial in 36 patients with cocaine-associated chest pain, the early use of lorazepam together with glyceryl trinitrate was more efficacious than glyceryl trinitrate alone in relieving the chest pain (28C ). These findings contrast with those of an earlier study in which there was no evidence of additional benefit from diazepam in managing cocaine-related chest pain (29C ).

44. Sato M, Numachi Y, Hamamura T. Relapse of paranoid psychotic state in methamphetamine model of schizophrenia. Schizophr Bull 1992; 18: 115–22. 45. Ujike H. Stimulant-induced psychosis and schizophrenia: the role of sensitization. Curr Psychiatry Rep 2002; 4: 177–84. 46. Toomey R, Lyons MJ, Eise SA, Xian H, Chantarujikapong S, Seidman LJ, Faraone SV, Tsuang MT. A twin study of the neuropsychological consequences of stimulant abuse. Arch Gen Psychiatry 2003; 60: 303–10. 47. Newton P, Chierakul W, Ruangveerayuth R, Abhigantaphand D, Looareesuwan S, White NJ.

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