Animal Models in Toxicology by Shayne C. Gad

By Shayne C. Gad

Notwithstanding i've got but to learn the booklet in its entirety, i've got skimmed via a number of chapters & i locate that a lot of the thoughts seem to be written in redundancy. probably i've got excessive expectancies, yet might be innovations which are played within the comparable demeanour among species can be consolidated and referenced. the data for real toxicology within the a number of species is especially necessary.

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The human) will reduce the predictive value of the test results. From a practical standpoint, often the pharmacokinetics are unknown in humans or the variety of available test species at the time of species selection. For this reason, testing is usually conducted in at least two species. Generally, one of those species is usually a rodent and one a nonrodent. The two most commonly used rodent species are mice and rats, and often toxicity testing is conducted in both of those species. Mice have many advantages as test animals for toxicity testing.

1989). Cellular and molecular aspects of glucuronidation, Colloque Inserm, Vol. 173. London: John Libbey Eurotext. Singer, S. (1985). Preparation and characterization of the different kinds of sulfotransferases. In Biochemical pharmacology and toxicology, Vol. I, eds. D. Zakim and D. Vessay, 95–159. New York: Wiley Interscience. , and Gandolfi, A. (1986). Biotransformation of toxicants. In Casarett and Doull’s toxicology: The basic sciences of poisons, eds. C. Klaassen, M. Amdur, and J. Doull, 64–98.

Annl. NY Acad. Sci. 406, 48–58. Fano, A. (1998). Lethal laws. New York: Zed Books. Frazier, J. M. (1990). In vitro toxicology. New York: Marcel Dekker. Gad, S. C. (1989). A tier testing strategy incorporating in vitro testing methods for pharmaceutical safety assessment, humane innovations and alternatives in animal experimentation 3, 75–79. Gad, S. (2000). ). Philadelphia: Taylor & Francis. Gad, S. (2002). Drug safety evaluation. New York: Wiley. , and Chengelis, C. (1998). ). San Diego, CA: Academic Press.

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