Cerebellar Modules, Molecules, Morphology and Function by N M Gerrits

By N M Gerrits

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1996) Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K ÷ channels. Neuron, 16: 321-331. T. and Goldowitz, D. (1989) Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study. J. , 9: 1608-1620. T. and Goldowitz, D. (1990) Purkinje cell loss is due to a direct action of the weaver gene in Purldnje cells: evidence from chimeric mice. Dev. , 52:211-218. , Nakagawa, S. , Mishina, M. and Inoue, Y. (1996) Developmental changes in expression and distribution of the glutamate receptor channel ~2 subunit according to Purkinje cell maturation.

J. Comp. , 394:431-444. E. K. (1994) Otxl and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J. , 14: 5725-5740. Goldowitz, D. (1989) The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: evidence from homozygous weaver chimeras. Neuron, 2: 1565-1575. , Sassaville, R. and Hawkes, R. (1987) Parasagittal organization of the rat cerebellar cortex: a direct correlation between antigenic Purkinje cell bands revealed by mabQ113 and the organization of the olivocerebellar projection.

Fig. 2A, lower traces). , 1998). Thus as summarized in the frequency distribution histogram (Fig. 6% of wild-type PCs recorded in the present study (P22-P59) are innervated by one, two and three CFs, respectively. 1% had two and three discrete steps, respectively (Fig. 2B, left panel). The difference of CF innervation between the wild-type and Gaq mutant mice during P22-P59 could be due to the retardation of general cerebellar maturation in the Gaq mutant mice. To assess this possibility, we examined CF-EPSCs in older mice (P70-P109) (Fig.

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