Engineering of Functional Skeletal Tissues (Topics in Bone by Felix Bronner (Editor), Mary C. Farach-Carson (Editor),

By Felix Bronner (Editor), Mary C. Farach-Carson (Editor), Antonios G. Mikos (Editor)

This is often the third quantity in a sequence of reports founded at the unmarried significant subject of bone substitute, discussing the biology of stem cells and cellphone signs, the information had to make stem cell-engineered bone tissue a truth, and the way to avoid bone allograft an infection. important as a followup to its predecessors, and as a stand-alone reference, it's going to curiosity a vast viewers from orthopedists and bioengineers to dentists.

Show description

Read Online or Download Engineering of Functional Skeletal Tissues (Topics in Bone Biology, 3) PDF

Best technique books

North American Sabre Jet F-86D/K/L Part One: Design / Structure / Testing (Air Force Legends Number 202)

;North American Sabre Jet F-86D/K/L half One: layout / constitution / trying out (Air strength Legends quantity 202) ВОЕННАЯ ИСТОРИЯ,ТЕХНИКА Название: North American Sabre Jet F-86D/K/L half One: layout / constitution / trying out (Air strength Legends quantity 202)Автор: Ray WagnerИздательство: Ginter BooksISBN: 094261299XГод: 1999Страниц: 100Формат: PDF в RARРазмер: 124.

Petroleum Production Systems

Written via petroleum construction engineers with huge business in addition to instructing event, this can be the single on hand complex and complete engineering textbook for petroleum reservoir and construction engineering. offers vast assurance of good deliverability from oil, fuel and two-phase reservoirs, wellbore movement functionality, smooth good attempt and construction log research, matrix stimulation, hydraulic fracturing, synthetic raise and environmental issues.

Additional resources for Engineering of Functional Skeletal Tissues (Topics in Bone Biology, 3)

Example text

This indicates that VEGFR1 has a role in monocyte migration [15]. Because osteoblasts express both VEGF receptors and neuropilin 1 [80], the decrease in osteoblasts at the growth plates in anti-VEGF-treated mice reflects an impairment of VEGFR or neuropilin signaling. This in turn has impaired recruitment and/or differentiation of these cell types. Thus, VEGF contributes importantly not only to angiogenesis, but also to osteogenesis. In mice lacking the VEGF gene, the long bones demonstrate a disturbed vascular pattern at birth, consistent with reduced bone growth [140].

The intracellular effects of FGFs are mediated by two signaling pathways: the mitogenactivated protein kinase/ERK kinase 1 (MEK1) pathway and the Janus kinase-signal transducer and activator of transcription (JAKSTAT) pathway [152, 165, 182]. The JAK-STAT signaling pathway mediates the ability of FGF signaling to inhibit chondrocyte proliferation and enhances hypertrophic chondrocyte apoptosis, whereas the MEK1 pathway mediates FGF inhibition of hypertrophic differentiation. A number of studies have examined whether FGF has utility in promoting bone formation.

The TNF family members with the most homogeneity are TNF-α, TNF-β (LT-α), and LT-β. Both TNF-α ligands and TNF-β (LT-α) are homotrimers, whereas LT-β is a heterotrimer of (LT-α)1(LT-β)2. There are three receptors in this family: TNFR1/p55/death receptor 1/ DR1, TNFR2 (p75), and LT-β receptor. Both TNF ligands bind both TNF receptors, but LTβ/TNF-α trimers only bind to the LT receptor. FasL is a unique family member and is solely recognized by its receptor, FAS/Apo1/DR2 [211]. Most cells express TNF-α and its receptors, but the expression of TNF-β and its receptor appears to be restricted to T cells and natural killer cells.

Download PDF sample

Rated 4.85 of 5 – based on 38 votes