By Veronique Gouverneur, Veronique Gouverneur, Klaus Muller
Fluorine chemistry is an increasing region of analysis that's attracting foreign curiosity, a result of impression of fluorine in drug discovery and in medical and molecular imaging (e.g. puppy, MRI). Many researchers and lecturers are coming into this region of study, whereas scientists in business and scientific environments also are in some way uncovered to fluorine chemistry by utilizing fluorinated compounds for imaging.
This publication offers an summary of the impression that fluorine has made within the lifestyles sciences. within the first part, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates grants precious info at a molecular point. the next chapters offer solutions to the main questions posed at the value of fluorine in drug discovery and medical functions. For examples, the reader will detect how fluorine has discovered its position as a key point enhancing drug efficacy, with regards to a number of the best-selling medicinal drugs out there. eventually, an intensive assessment at the layout, synthesis and use of 18F-radiotracers for positron emission tomography is supplied, and this is often complemented with a dialogue on how 19F NMR has complex molecular and scientific imaging.
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Extra resources for Fluorine in Pharmaceutical and Medicinal ChemistryFrom Biophysical Aspects to Clinical Applications
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JUN, FOS and GCN4, they play an important role in gene transcription. Long coiled coils may serve as molecular springs and as scaffolds that make up the cytoskeleton (Rose and Meier, 2004). Moreover, coiled coil structures are also involved in the membrane fusion of viruses such as HIV-1 with host cells (Esté and Telenti, 2007). , 1991). 1. (a) Crystal structure of the GCN4 leucine zipper (PDB code 2ZTA), (b) GCN4 backbone viewed from the N- to the C-terminus along the superhelical axis, (c) helical wheel representation of (b) depicting the heptad repeat pattern (reproduced from M.