By Charles G. D. Brook, Mehul T. Dattani(auth.)
Chapter 1 The Relevance of Molecular Biology to scientific perform (pages 1–14):
Chapter 2 Hormones: Their Nature, motion and size (pages 15–30):
Chapter three The Hypothalamo?Pituitary Axis (pages 31–47):
Chapter four Endocrine difficulties of Infancy (pages 48–69):
Chapter five The administration of progress problems (pages 70–98):
Chapter 6 The administration of Puberty issues (pages 99–128):
Chapter 7 The Thyroid Gland (pages 129–150):
Chapter eight The Adrenal Gland (pages 151–174):
Chapter nine issues of Calcium and Bone Metabolism (pages 175–209):
Chapter 10 Water stability (pages 210–229):
Chapter eleven Hypoglycemia (pages 230–247):
Chapter 12 weight problems and sort 2 Diabetes Mellitus (pages 248–266):
Chapter thirteen variety 1 Diabetes Mellitus (pages 267–295):
Chapter 14 Endocrine Neoplasia (pages 296–308):
Chapter 15 exams and common Values in Pediatric Endocrinology (pages 309–324):
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Extra resources for Handbook of Clinical Pediatric Endocrinology, Second Edition
Over the years, many improvements have been implemented. Originally, the tracer in IA and IMA was labeled with radionuclides but enzymes, fluorescent and chemoluminescent labels are now used. These labels may be coupled directly or indirectly through biotin–streptavidin coupling. Owing to the catalytic effect in enzymebased assays, it is possible for small amounts of bound enzyme to metabolize large quantities of substrate. The most common endpoint used in both IAs and IMAs is chemiluminescence.
However, some of the ligands also have non-genomic actions acting over a shorter timeframe. g. aldosterone activation of the Na+/H+ exchanger. Intracellular receptors consist of three major regions: a highly variable N-terminal domain, which can lead to transcriptional activation; a DNAbinding domain (DBD); and a C-terminal ligand binding domain (LBD). ” There are two classes of intracellular receptor. Class I includes the mineralocorticoid, progesterone, androgen, glucocorticoid and estrogen receptors; class II includes vitamin D, retinoic acid and thyroid hormone receptors.
Pulsatile release of hypothalamic GnRH regulates the secretion of LH and FSH which stimulate the testis and ovary at puberty to increase the gonadal steroid secretion and develop secondary sexual characteristics. There is a surge in gonadotropin and gonadal steroid secretion in the neonatal period with concentrations similar to those reached during puberty. Following the first few months of life, the gonadotropin axis remains quiescent until puberty, when concentrations rise again. Estradiol and progesterone act via both the pituitary and hypothalamus to have a negative 1/30/2012 11:21:03 PM 38 CHAPTER 3 The Hypothalamo-Pituitary Axis effect on gonadotropin secretion.