By M. Tubiana (auth.), Professor Georges Mathé, Professor Maxime Seligmann, Dr. Maurice Tubiana (eds.)
We have studied 24 circumstances of secondarily leukemic (stage V) lymphosarcoma (LS), 31 circumstances of "d'emblee" leukemic LS, and ten situations of lymphoid leukemic neoplasias transitional among "d'emblee" leukemic LS and persistent lymphocytic leukemia (eLL). those instances merely challenge the typical varieties ofthe WHO class ofLS, i.e., the prolymphocytic, the lymphoblastic, and the immunoblastic. a few circumstances have additionally been categorized by means of mobilephone floor markers. The secondarily leukemic conversion happened in forty% of the lymphoblastic forms, in 14% of the prolymphocytic varieties, and in 17% of the immunoblastic varieties. It by no means happened at degree I yet may possibly happen after the other level. The mediastinal involvement used to be saw in 3 varieties, yet as a rule within the lymphoblastic variety. The analysis after an acute lymphoid leukemia (ALL) therapy comprising lively immunotherapy following chemo(radio)therapy is best for the leukemic prolymphocytic and lymphoblastic LS than for the immunoblastic kind. sufferers (one of the lymphoblastic variety) are in whole remission after eight and five years, respectively. we've got defined ten instances of "d'emblee" leukemic LS with both huge lymphoid or additional lymphoid lots, bone marrow leukemic mobile involvement, and LS elements of neoplastic cells. Mediastinal, belly, or different tumor lots are frequent.
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Quantitation of differential sensitivity of human tumor cells to anticancer drugs. N. Eng!. J. Med. 298, 1321-1327 (1978) 21. , BERGSAGEL, D. : Kappa and lambda light chain disease: Survival rates and clinical manifestations. Blood 48, 41-51 (1976) 22. SKIPPER, H. : Thoughts on cancer chemotherapy and combination modality therapy (1974). J. Am. Med. Assoc. 230, 1033-1035 (1974) 23. SULLIVAN, P. , SALMON, S. : Kinetics of tumor growth and regression in IgG multiple myeloma. J. Clin. Invest. 51,1697-1706 (1972) Staging of Myeloma.
This was followed by intermittent chemotherapy in which the rate of cyclophosphamide administration was secondarily adapted to hematologic tolerance. Twentyseven patients were treated according to regimen C which consists of continuous chemohormonotherapy combining the same previous daily dose of 20 mg/m 2 prednisone, with an initial daily dose of 3 mg/m 2 melphalan up to maximum hematologic tolerance (2500 WBC). This was 60 mg/m 2 per day x 7 60 mg/m 2 per day 4 mg/m 2 per day x 7 A B C D 40 mg/m 2 per day x 7 20 mg/m 2 per day 20 mg/m 2 per day 40 mg/m 2 per day x 7 Prednisone (PDN) "Sequential "PAPE" regimen with cycles ofCPM x 7/day, MPH x 7/day, PDN x 7/day.
Clin. Lab. Invest. : Diagnosis and treatment of multiple myeloma. New York, London, Grune and Stratton (1970) Prognostic Factors and Treatment of Multiple Myeloma: Interest of a Cyclic Sequential Chemohormonotherapy Combining Cyclophosphamide, Melphalan, and Prednisone D. BELPOMME, F. SIMON, P. POUILLART, B. AMOR, F. FEUILHADE DE CHAUVIN, A. BELPOMME, C. MENKES, A. DELRffiU, R. DEPIERRE, B. LE MEVEL, B. SERROU, D. FRIES, F. DELBARRE, and O. MATHE Introduction In 1889, KAUfER succeeded in establishing the relationship between Bence Jones proteinuria , discovered in 1845, and the bone "tumor," called "multiple myeloma" by RUSTISKY in 1873 .