Malignant Tumors of the Thyroid: Clinical Concepts and by Alex Stagnaro-Green (auth.), Rhoda H. Cobin M.D., David King

By Alex Stagnaro-Green (auth.), Rhoda H. Cobin M.D., David King Sirota M.D. (eds.)

Thyroid carcinoma is an unusual malignan­ ing the on hand non-human traces, as types cy. within the overwhelming majority of sufferers, if taken care of for mobile cycle reviews and oncogene/anti­ thoroughly, it really is linked to a benign oncogene legislation, simply because they're unaware scientific path. Why then does it carry a con­ of the usually primary dichotomy among tinuing fascination for thus many physicians? thyroid malignancy and analysis. 3rd, the the answer's most likely without delay based very nature of the benign medical path has instructed to the foremost overall healthiness examine fund­ at the very benign nature of such a lot thyroid ing businesses that thyroid melanoma isn't beneficial maligllancies. whereas there are poor excep­ of analysis in a time of scarce assets. tions, the follicular and papillary thyroid can­ not anything should be farther from the reality. cers behave in a fashion really alien to "common" This pleasing scientific direction is the very cause neoplasia, for the reason that they develop and metastasize why the examine of human thyroid melanoma has the slowly. We think that if basically lets below­ strength for contributing additional to our enjoyable­ stand this sort of reworked kingdom, we'd be able to examine very much concerning the basic and damental realizing of malignancy and, irregular law of the mobilephone cycle and im­ maybe extra importantly, the mechanisms by means of turn out our knowing of melanoma. which the human physique can face up to neoplastic although, contemporary advances within the biology of cells.

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Extra info for Malignant Tumors of the Thyroid: Clinical Concepts and Controversies

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Aside from cancer, the effects of radiation on the thyroid gland include hyperplasia, benign adenomas, colloid nodules (usually microfollicular in type), and oxyphilic cell changes (perhaps secondary to autoimmunity) involving the release of thyroglobulin and microsomal fractions. Invasion of the thyroid gland by lymphocytes occurs, producing a clinical picture consistent with thyroiditis. Fibrosis occurs; although in most glands it is found to be minimal, with thickening of the septa. These changes occur in multiple areas of the thyroid gland and give rise to multiple nodules within the gland.

Surgery 1985;98: 1171-1178. 56. Schmidt RJ, Wang CA. Encapsulated follicular carcinoma of the thyroid: diagnosis, treatment, and results. Surgery 1986;100:1068-1077. 57. Schlumberger M, Tubiana M, DeVathaire F, et al. Long term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma. JCEM 1986;63:960-967. 58. Schlumberger M, DeVathaire F, Travagli JP, Vassal G, et al. Differentiated thyroid carcinoma in childhood: Long term follow-up of 72 patients.

Thompson NW, Nishiyama RH, Harness JK. Thyroid carinoma: Current controversies. In: Ravitch MM, Steicher FM, eds. Current problems in Surgery 15, No. 11. Chicago: Yearbook Medical Publishers, 1978:1-15. 22. Cady B, Sedgwick CD, Meissner WA, Bookwalter JR, Romagosa V, Werber J. Changing clinical, pathologic, therapeutic, and survival patterns in differentiated thyroid carcinoma. Ann Surg 1976; 184:541-553. 23. Boehm T, Rothouse L, Wartofsky L. Metastatic occult follicular thyroid carcinoma. JAMA 1976;235:24202421.

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