Principles of Biochemical Toxicology, 3rd Edition by John Timbrell

By John Timbrell

Learn into the biochemical foundation of toxicology has elevated quickly over contemporary years, amidst issues over the hostile results of substances, environmental toxins and occupational dangers. Following the acclaimed first variations of rules of Biochemical Toxicology, the writer has increased the textual content to incorporate precis sections, questions and version solutions and carefully revised art. those beneficial properties, plus the recent easy-to-read structure, will make biochemical toxicology extra available to undergraduates and postgraduates encountering the topic for the 1st time. This accomplished textbook offers an intensive clarification of dose-response relationships, disposition and metabolism, poisonous responses to overseas compounds and precise examples to demonstrate mechanisms of toxicity. scholars and academics will locate the transparent and concise procedure, which confirmed this booklet because the major textbook in its box, a vital reduction to studying and educating.

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Principles of Biochemical Toxicology, 3rd Edition

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In contrast, strong acids and bases are not usually appreciably absorbed from the gastrointestinal tract by passive diffusion. 16). Sufficient paraquat is absorbed from the gastrointestinal tract after oral ingestion for fatal poisoning to occur, but the nature of the Sites of absorption transport systems for both of these compounds are currently unknown although carrier-mediated transport is perhaps the most likely (see Chapter 7). Carrier-mediated transport systems important for foreign, toxic compounds are known to operate in the gastrointestinal tract.

15). Consequently, weak acids are generally fairly well absorbed from the small intestine. In contrast, strong acids and bases are not usually appreciably absorbed from the gastrointestinal tract by passive diffusion. 16). Sufficient paraquat is absorbed from the gastrointestinal tract after oral ingestion for fatal poisoning to occur, but the nature of the Sites of absorption transport systems for both of these compounds are currently unknown although carrier-mediated transport is perhaps the most likely (see Chapter 7).

The gut bacteria may also reduce nitrates to nitrites, which can cause methaemoglobinaemia or may react with secondary amines in the acidic environment of the gut, giving rise to carcinogenic nitrosamines. Conversely, the acidic conditions of the gut may inactivate some toxins, such as snakevenom, which is hydrolysed by the acidic conditions. 8). Extensive metabolism in the liver may alter the structure of the compound, making it more or less toxic. Little of the parent compound reaches the systemic circulation in these circumstances.

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